antihaemophilic globulin

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antihaemophilic globulin

A scientist carefully measures antihaemophilic globulin in a laboratory.

Definition

Noun: - A coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A: Antihaemophilic globulin is a specific protein found in blood plasma that is essential for the normal clotting of blood. It is also known medically as Factor VIII. A deficiency or dysfunction of this factor causes the bleeding disorder hemophilia A.

Usage
  • This term is used primarily in medical, clinical, and biological contexts to refer to the blood clotting factor.
  • It is often discussed in relation to diagnosis, treatment, and the pathology of coagulation disorders.
Examples
  • The patient's bleeding disorder was diagnosed as a severe deficiency in antihaemophilic globulin.
  • Treatment for classic hemophilia involves intravenous infusion of concentrated antihaemophilic globulin.
  • The laboratory test measures the activity level of antihaemophilic globulin in the blood plasma.
Advanced Usage
  • Genetic basis: The production of antihaemophilic globulin is controlled by a gene on the X chromosome, which is why hemophilia A predominantly affects males.
  • Therapeutic use: Recombinant antihaemophilic globulin is produced through biotechnology for use in replacement therapy, reducing the risk of infections that were associated with plasma-derived products.
Variants and Related Words
  • Factor VIII: The standard medical and scientific synonym for antihaemophilic globulin.
  • Antihemophilic factor (AHF): Another common synonym, using the American English spelling 'antihemophilic'.
  • Hemofil: A well-known trade name for a therapeutic preparation of this factor.
  • Coagulation factor: The general category of proteins to which antihaemophilic globulin belongs.
Synonyms
  • Factor VIII
  • Antihemophilic factor (AHF)
  • Platelet cofactor I (an older, less common term)
Notes on Different Meanings
  • This term has a single, highly specific meaning in hematology and medicine. It does not have general or figurative uses outside this field.
  • The spelling 'antihemophilic globulin' (with a single 'e') is the common American English variant. The provided term 'antihaemophilic globulin' uses the British English spelling with 'ae'.
antihaemophilic globulin

A scientist carefully measures antihaemophilic globulin in a laboratory.

Noun
  1. a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A

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