Paget's disease

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Definition

Noun: 1. A chronic bone disorder: Paget's disease of bone is a condition that disrupts the normal cycle of bone renewal. In this disease, the process of breaking down old bone and forming new bone becomes abnormally fast, leading to bones that are larger, weaker, and more fragile than normal bone. 2. A specific medical condition: The term "Paget's disease" most commonly refers to this bone disorder. It is named after Sir James Paget, the surgeon who first described it.

Usage Examples
  • Noun:
    • The X-ray revealed signs of Paget's disease in his pelvis.
    • A common symptom of Paget's disease is bone pain.
    • Treatment for Paget's disease focuses on controlling the excessive bone turnover.
Advanced Usage
  • "Complications of Paget's disease": Refers to the secondary problems that can arise from the condition, such as arthritis, hearing loss (if skull bones are affected), or heart failure in severe cases.
    • The patient was monitored for potential complications of Paget's disease.
  • "Monostotic vs. polyostotic Paget's disease": Medical terms describing whether the disease affects a single bone (monostotic) or multiple bones (polyostotic).
    • Polyostotic Paget's disease is more common than the monostotic form.
Variants and Related Words
  • Osteitis deformans: This is the alternative medical name for Paget's disease of bone.
  • Paget's disease of the breast: A separate, unrelated condition also named after Sir James Paget. It is a rare form of breast cancer involving the skin of the nipple. Note: This is a distinct disease and must be specified clearly to avoid confusion with the bone disorder.
Synonyms
  • Osteitis deformans (medical synonym)
Related Terms and Context
  • Bone remodeling: The normal, continuous process of bone resorption and formation that Paget's disease disrupts.
  • Bisphosphonates: A class of drugs commonly used to treat Paget's disease by slowing down the excessive bone breakdown.
  • Alkaline phosphatase: A blood enzyme often elevated in people with active Paget's disease, used as a marker for diagnosis and monitoring.
Noun
  1. a disease of bone occurring in the middle aged and elderly; excessive bone destruction sometimes leading to bone pain and fractures and skeletal deformities

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