von willebrand's disease
Definition
Noun: A hereditary bleeding disorder caused by a deficiency or defect in von Willebrand factor, a blood protein crucial for proper clotting. This condition is characterized by prolonged bleeding time, frequent nosebleeds, easy bruising, and excessive bleeding from mucous membranes.
Usage
The term "von Willebrand's disease" is used as a medical diagnosis to classify a specific type of coagulation disorder distinct from hemophilia. * She was diagnosed with von Willebrand's disease after experiencing heavy menstrual bleeding. * Management of von Willebrand's disease often involves medication to increase clotting factor levels.
Advanced Usage
- Abbreviation: Commonly abbreviated as VWD in medical literature and charts.
- The patient's history of VWD was noted prior to surgery.
Variants and Related Words
- von Willebrand factor (VWF) (noun): The specific blood plasma glycoprotein that is deficient or defective in this disease. It mediates platelet adhesion and carries clotting factor VIII.
- Acquired von Willebrand syndrome (noun): A non-hereditary form of the condition that can develop later in life due to other medical issues, such as autoimmune diseases.
Synonyms
- Pseudohemophilia (noun, dated/less common): An older term reflecting its similarity to, but distinction from, classical hemophilia.
- Angiohemophilia (noun, dated/rare): Another historical term.
Related Phrases
- Type 1/2/3 von Willebrand's disease: Refers to the classification of the disease based on the severity and nature of the von Willebrand factor deficiency.
- Type 1 is the mildest and most common form of von Willebrand's disease.
Noun
-
a form of hemophilia discovered by Erik von Willebrand; a genetic disorder that is inherited as an autosomal recessive trait; characterized by a deficiency of the coagulation factor and by mucosal bleeding
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