antihaemophilic globulin
Definition
Noun: - A coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A: Antihaemophilic globulin is a specific protein found in blood plasma that is essential for the normal clotting of blood. It is also known medically as Factor VIII. A deficiency or dysfunction of this factor causes the bleeding disorder hemophilia A.
Usage
- This term is used primarily in medical, clinical, and biological contexts to refer to the blood clotting factor.
- It is often discussed in relation to diagnosis, treatment, and the pathology of coagulation disorders.
Examples
- The patient's bleeding disorder was diagnosed as a severe deficiency in antihaemophilic globulin.
- Treatment for classic hemophilia involves intravenous infusion of concentrated antihaemophilic globulin.
- The laboratory test measures the activity level of antihaemophilic globulin in the blood plasma.
Advanced Usage
- Genetic basis: The production of antihaemophilic globulin is controlled by a gene on the X chromosome, which is why hemophilia A predominantly affects males.
- Therapeutic use: Recombinant antihaemophilic globulin is produced through biotechnology for use in replacement therapy, reducing the risk of infections that were associated with plasma-derived products.
Variants and Related Words
- Factor VIII: The standard medical and scientific synonym for antihaemophilic globulin.
- Antihemophilic factor (AHF): Another common synonym, using the American English spelling 'antihemophilic'.
- Hemofil: A well-known trade name for a therapeutic preparation of this factor.
- Coagulation factor: The general category of proteins to which antihaemophilic globulin belongs.
Synonyms
- Factor VIII
- Antihemophilic factor (AHF)
- Platelet cofactor I (an older, less common term)
Notes on Different Meanings
- This term has a single, highly specific meaning in hematology and medicine. It does not have general or figurative uses outside this field.
- The spelling 'antihemophilic globulin' (with a single 'e') is the common American English variant. The provided term 'antihaemophilic globulin' uses the British English spelling with 'ae'.
Noun
-
a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A
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