de novo

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de novo

A scientist starts a de novo synthesis of a protein in the lab.

Definition
  1. Adverb:
    • From the beginning; anew; starting over: This term is used to indicate that something is being done again from the start, without relying on previous assumptions, data, or conditions. It often implies a fresh, independent approach.
Usage
  • The term 'de novo' is primarily used in formal, academic, or professional contexts, especially in law, science, and medicine.
  • It describes an action, review, or process that begins completely anew.
  • It is typically placed before the verb or adjective it modifies.
Examples
  • Adverb:
    • The court ordered a de novo review of the case, meaning the higher court would examine all the evidence as if the lower court had never ruled.
    • The research team decided to analyze the data de novo, without using any of the prior flawed assumptions.
    • After the system failure, the engineers had to design the software module *de novo.
Advanced Usage
  • Legal Context: A 'de novo' trial or appeal is one where the court retries the case as if it were new, considering both facts and law without deference to the lower court's decision.
  • Scientific/Biological Context: 'De novo' synthesis refers to the biochemical process of creating complex molecules from simple precursors, rather than by modifying existing molecules. 'De novo' mutation is a genetic alteration present for the first time in a family member.
  • General Formal Use: Can be used to describe any process started completely from scratch.
    • The company's strategy failed, forcing them to rebuild their business plan *de novo.
Variants and Related Words
  • Denovo (sometimes written as one word, though "de novo" is standard).
  • Anew (adverb): In a new or different, typically more positive, way; once more.
  • Afresh (adverb): In a new or different way; again from the beginning.
Synonyms
  • From scratch
  • Anew
  • Afresh
  • Over again
  • Ab initio (a Latin synonym with similar meaning, used in legal contexts)
Notes
  • 'De novo' is a Latin phrase adopted into English. It is often italicized in formal writing ().
  • It functions solely as an adverb in English and does not have noun, verb, or adjective forms derived from it in common usage.
  • Avoid confusing it with similar-sounding words like "novel" (new and original).
de novo

A scientist starts a de novo synthesis of a protein in the lab.

Adverb
  1. from the beginning