diethylstilbesterol

Thân thiện

A doctor explains the history of diethylstilbesterol to a medical student.

Definition

1. Noun:
   • A synthetic, nonsteroidal compound possessing estrogenic properties. It was historically prescribed for various gynecological and obstetric conditions but is now known to be associated with serious health risks, particularly vaginal cancer in the female offspring of women who took it during pregnancy.

Usage Examples

• Noun:
  • Diethylstilbesterol was once commonly prescribed to prevent miscarriages.
  • The use of diethylstilbesterol was discontinued after its carcinogenic effects were discovered.
  • Many women exposed to diethylstilbesterol in utero require specialized medical monitoring.

Advanced Usage

• "DES exposure": Refers to the condition of having been prenatally exposed to diethylstilbesterol.
  • DES exposure has been linked to an increased risk of certain reproductive tract abnormalities.
• "DES daughter": A term for a woman whose mother took diethylstilbesterol during pregnancy.
  • As a DES daughter, she participates in a long-term health study.

Variants and Related Words

• DES: A common acronym for diethylstilbesterol.
  • The DES tragedy led to major reforms in drug safety testing.
• Stilbestrol: An older, alternative name for the same compound.
• Synthetic estrogen: The broader class of compounds to which diethylstilbesterol belongs.

Synonyms

• Stilboestrol (primarily British English spelling)
• DES
• Synthetic estrogen (general category)

Related Phrases and Terms

• DES-associated clear cell adenocarcinoma: The specific type of vaginal cancer linked to prenatal DES exposure.
• DES litigation: Refers to the lawsuits filed against pharmaceutical companies that manufactured and marketed the drug.

Học thuật

Noun

1. synthetic nonsteroid with the properties of estrogen; formerly used to treat menstrual problems but was found to be associated with vaginal cancers in the daughters of women so treated during pregnancy

Từ đồng nghĩa

• DES
• stilbesterol