factor X

Học thuật
Thân thiện
Definition
  1. Noun:
    • A coagulation factor in blood plasma: Factor X is a specific protein (specifically, a zymogen) that plays a crucial role in the middle phase of the blood coagulation cascade. It is activated to form the enzyme factor Xa.
    • An enzyme precursor in the clotting process: It is converted to its active form, factor Xa, which then converts prothrombin to thrombin, a key step in forming a blood clot.
Usage Examples
  • Noun:
    • A deficiency in factor X can lead to a rare bleeding disorder.
    • The drug works by inhibiting the activity of activated factor X (factor Xa).
    • Factor X is synthesized in the liver and requires vitamin K for its production.
Advanced Usage

  • "Activated factor X (factor Xa)": This is the active enzyme form of factor X, which directly cleaves prothrombin.

    • Direct oral anticoagulants often target factor Xa to prevent thrombosis.

  • "Factor X deficiency": A medical term for a hereditary bleeding disorder caused by insufficient or dysfunctional factor X.

    • Patients with factor X deficiency may experience symptoms ranging from mild to severe.
Variants and Related Words
  • Stuart-Prower factor: An alternative name for factor X, named after the first two patients diagnosed with its deficiency.
  • Coagulation factor: The general category to which factor X belongs. Other examples include factor VIII and factor IX.
  • Prothrombinase complex: The enzymatic complex (composed of factor Xa, factor Va, calcium ions, and a phospholipid surface) that converts prothrombin to thrombin.
Synonyms
  • Coagulation factor X: The full technical term.
  • Stuart factor: A common synonym in medical literature.
Related Phrases
  • "Extrinsic pathway": One of the two initial pathways that lead to the activation of factor X.
  • "Intrinsic pathway": The other initial pathway that converges to activate factor X.
  • "Common pathway": The final coagulation pathway that begins with the activation of factor X.
Notes
  • Factor X is a vitamin K-dependent clotting factor.
  • Its position at the start of the common pathway makes it a critical control point in coagulation, and thus a major target for anticoagulant therapies.
Noun
  1. coagulation factor that is converted to an enzyme that converts prothrombin to thrombin in a reaction that depends on calcium ions and other coagulation factors

Từ đồng nghĩa

Từ gần giống

Từ chứa "factor X"