factor viii
Definition
Noun: 1. A specific blood clotting protein: Factor VIII is a protein in the blood plasma that is essential for the normal clotting of blood. It acts as a cofactor for another clotting factor (Factor IX) in the coagulation cascade. 2. A deficient substance in Hemophilia A: The absence or dysfunction of this specific factor is the cause of the inherited bleeding disorder known as Hemophilia A.
Usage Examples
- Noun:
- Patients with severe Hemophilia A have less than 1% of normal factor VIII activity in their blood.
- The doctor ordered an infusion of recombinant factor VIII to control the bleeding episode.
- Laboratory tests measure the level of factor VIII to diagnose the severity of the clotting disorder.
Advanced Usage
- "Factor VIII concentrate": A therapeutic product derived from human plasma or produced recombinantly, used to treat or prevent bleeding in individuals with Hemophilia A.
- Prophylactic treatment with factor VIII concentrate has significantly improved the quality of life for many patients.
- "Factor VIII inhibitor": An antibody developed by some patients with Hemophilia A that neutralizes infused factor VIII, making treatment less effective.
- The development of a factor VIII inhibitor is a serious complication of treatment.
Variants and Related Words
- Antihemophilic factor (AHF): An older, alternative name for factor VIII.
- Hemofil: A historical brand name for a plasma-derived factor VIII concentrate.
- Coagulation factor VIII: The full technical term.
- FVIII: A common abbreviation used in medical literature.
Synonyms
- Antihemophilic factor (AHF)
- Coagulation factor VIII
Note: While "Hemofil" is listed as a trade name in the reference, it is a specific product brand and not a general synonym for the protein itself.
Noun
-
a coagulation factor (trade name Hemofil) whose absence is associated with hemophilia A
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