fibrinase

Thân thiện

A scientist observes fibrinase activity in a laboratory blood sample.

Definition

Noun: 1. An enzyme: A specific enzyme (factor XIIIa) that is the activated form of blood coagulation factor XIII. Its primary function is to stabilize a blood clot by forming covalent bonds between fibrin molecules, making the clot strong and resistant to premature breakdown.

Usage

Noun: * The final step in clot stabilization involves the action of fibrinase. * A deficiency in fibrinase can lead to abnormal bleeding because clots are not properly stabilized.

Advanced Usage

• In medical/biological contexts: The term is used almost exclusively in hematology, physiology, and clinical medicine when discussing the detailed biochemistry of blood coagulation. It is a specialized term for the active form of "factor XIII."
  • Example: "The conversion of fibrinogen to fibrin is followed by the cross-linking action of fibrinase."

Variants and Related Words

• Factor XIIIa: This is the more precise and commonly used scientific synonym for fibrinase. "Factor XIII" refers to the inactive precursor (zymogen), while "Factor XIIIa" (where 'a' stands for 'activated') is the active enzyme.
• Transglutaminase: Fibrinase belongs to the broader family of transglutaminase enzymes, which catalyze the formation of bonds between proteins.

Synonyms

• Factor XIIIa
• Plasma transglutaminase (in this specific context)
• Fibrin-stabilizing factor (an older term)

Antonyms

• Fibrinolysin (e.g., plasmin): An enzyme that breaks down fibrin clots, representing the opposing process in the body's regulation of clotting.
• Anticoagulant: A substance that prevents or slows down blood clotting (e.g., heparin, warfarin).

Notes on Meaning

• Primary Meaning: In all contexts, "fibrinase" refers specifically to the enzyme factor XIIIa in the blood coagulation cascade.
• No Common Idioms or Phrasal Verbs: As a highly technical biochemical term, "fibrinase" is not used in idiomatic expressions or phrasal verbs.

Học thuật

Noun

1. in the clotting of blood thrombin catalyzes factor XIII into its active form (fibrinase) which causes fibrin to form a stable clot

Từ đồng nghĩa

• factor xiii