The word "O" has a few different meanings, and I will explain them clearly for you.
Blood Type: "O" refers to a blood group. People with type O blood have red blood cells that do not have A or B antigens. Because of this, individuals with type O blood can donate blood to anyone, making them "universal donors."
Letter: "O" is the 15th letter of the Roman alphabet. It is a vowel.
Element: In chemistry, "O" stands for oxygen, a nonmetallic element that is essential for life on Earth. Oxygen is a colorless, odorless gas that makes up about 21% of the Earth's atmosphere.