oncogene
Definition
Noun: A gene that, when mutated or expressed at high levels, can contribute to turning a normal cell into a cancerous one. Oncogenes are derived from normal genes (proto-oncogenes) involved in cell growth and division.
Usage
An oncogene is a specific type of gene studied in biology and medicine. It is typically used in scientific, medical, and academic contexts to discuss the genetic basis of cancer. * The research focused on identifying which oncogene was responsible for the tumor's rapid growth. * A single mutated oncogene can sometimes initiate the development of cancer.
Advanced Usage
- Activation of an oncogene: Refers to the process by which a normal proto-oncogene becomes a cancer-promoting oncogene, often through mutation, amplification, or chromosomal rearrangement.
- The activation of the oncogene was linked to prolonged exposure to the chemical.
- Oncogene-driven cancer: Describes a type of cancer whose growth and survival are primarily dependent on the activity of a specific oncogene.
- The new drug is specifically effective against oncogene-driven lung cancers.
Variants and Related Words
- Proto-oncogene (noun): The normal, non-mutated counterpart of an oncogene. It regulates healthy cell growth and division.
- Oncogenic (adjective): Having the potential to cause cancer; relating to oncogenes.
- The virus has oncogenic properties.
Synonyms
- Cancer gene
- Transforming gene
Related Phrases and Concepts
- Tumor suppressor gene: A gene that protects a cell from becoming cancerous. It is often contrasted with an oncogene.
- Oncogene addiction: A concept where cancer cells become dependent on the continued activity of a specific oncogene for survival.
Noun
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a gene that disposes normal cells to change into cancerous tumor cells
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