oncogene

Thân thiện

A scientist points to an oncogene highlighted on a large DNA diagram.

Definition

Noun: A gene that, when mutated or expressed at high levels, can contribute to turning a normal cell into a cancerous one. Oncogenes are derived from normal genes (proto-oncogenes) involved in cell growth and division.

Usage

An oncogene is a specific type of gene studied in biology and medicine. It is typically used in scientific, medical, and academic contexts to discuss the genetic basis of cancer. * The research focused on identifying which oncogene was responsible for the tumor's rapid growth. * A single mutated oncogene can sometimes initiate the development of cancer.

Advanced Usage

• Activation of an oncogene: Refers to the process by which a normal proto-oncogene becomes a cancer-promoting oncogene, often through mutation, amplification, or chromosomal rearrangement.
  • The activation of the oncogene was linked to prolonged exposure to the chemical.
• Oncogene-driven cancer: Describes a type of cancer whose growth and survival are primarily dependent on the activity of a specific oncogene.
  • The new drug is specifically effective against oncogene-driven lung cancers.

Variants and Related Words

• Proto-oncogene (noun): The normal, non-mutated counterpart of an oncogene. It regulates healthy cell growth and division.
• Oncogenic (adjective): Having the potential to cause cancer; relating to oncogenes.
  • The virus has oncogenic properties.

Synonyms

• Cancer gene
• Transforming gene

Related Phrases and Concepts

• Tumor suppressor gene: A gene that protects a cell from becoming cancerous. It is often contrasted with an oncogene.
• Oncogene addiction: A concept where cancer cells become dependent on the continued activity of a specific oncogene for survival.

Học thuật

Noun

1. a gene that disposes normal cells to change into cancerous tumor cells

Từ đồng nghĩa

• transforming gene