sideroblastic anaemia
Definition
Noun A type of refractory anemia (a condition where the bone marrow fails to produce enough healthy red blood cells) characterized by the presence of ringed sideroblasts in the bone marrow. Ringed sideroblasts are red blood cell precursors that have abnormal iron deposits forming a ring around the nucleus.
Usage
The term is used in medical contexts to diagnose and describe a specific blood disorder. * The patient's fatigue and pallor were eventually attributed to sideroblastic anaemia. * A bone marrow biopsy is required to confirm a diagnosis of sideroblastic anaemia.
Advanced Usage
- The condition can be categorized as either hereditary (inherited) or acquired (developed later in life).
- It is often discussed in hematology as part of the myelodysplastic syndromes (MDS), a group of disorders where blood cells are poorly formed or don't work properly.
Variants and Related Words
- Sideroblastic anemia (noun): The American English spelling variant.
- Sideroblast (noun): The abnormal red blood cell precursor that defines the condition.
- Refractory anemia (noun): A broader category of anemias that do not respond to usual treatments, under which sideroblastic anaemia is classified.
Synonyms
- Sideroblastic anemia (noun): The direct spelling variant.
- Refractory anemia with ringed sideroblasts (RARS) (noun): A more precise clinical term often used interchangeably.
Related Phrases
- Ringed sideroblast (noun phrase): The specific pathological finding that defines the condition.
- Iron overload (noun phrase): A common complication of sideroblastic anaemia, as the iron intended for hemoglobin remains trapped in the bone marrow and can damage organs.
Noun
-
refractory anemia characterized by sideroblasts in the bone marrow
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