sticky end

Thân thiện

A scientist examines a DNA fragment with a sticky end under a laboratory light.

Definition

Noun: 1. A difficult, unpleasant, or disastrous conclusion or outcome: This is the primary figurative meaning. A "sticky end" refers to a situation that concludes with trouble, punishment, or death. 2. A specialized term in molecular biology: In genetics, a "sticky end" is the end of a DNA fragment where one strand of the double helix extends beyond the complementary strand. This single-stranded overhang can bind to a complementary sequence.

Usage and Examples

• Figurative Meaning (Difficult Outcome):

  • The villain in the story met a sticky end at the hands of the hero.
  • If you keep cheating, you'll come to a sticky end.
  • Their financial scheme led to a very sticky end for all the investors.

• Scientific Meaning (Molecular Biology):

  • The restriction enzyme EcoRI creates sticky ends with the sequence AATT.
  • DNA ligase can join two fragments if they have complementary sticky ends.

Advanced Usage

• The phrase is often used in a cautionary or moralistic tone to warn of the consequences of bad behavior.
• It is frequently found in narratives, especially in British English, to describe a character's unfortunate demise.

Variants and Related Words

• Sticky (adj): Having the property of adhering or causing difficulty.
• End (n): The final part of something.
• Blunt end (n, biology): The opposite of a sticky end in molecular biology; a DNA end where both strands are of equal length with no overhang.

Synonyms

• Bad end
• Unfortunate conclusion
• Grim fate
• Disastrous outcome

Idioms and Phrases

• To come to a sticky end: This is the most common phrasal form of the idiom.
  • He was involved with dangerous people and eventually came to a sticky end.

Học thuật

Noun

1. an end of DNA in which one strand of the double helix extends a few units beyond the other