anguish

/'æɳgwiʃ/
Noun
  1. extreme distress of body or mind
  2. extreme mental distress
Verb
  1. cause emotional anguish or make miserable
    • It pains me to see my children not being taught well in school
  2. suffer great pains or distress

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anguish
She clutched her head in anguish as she read the letter.