cyclooxygenase-1
Definition
- Noun:
- An enzyme that regulates prostaglandins important for stomach lining and kidney health: Cyclooxygenase-1 (often abbreviated as COX-1) is a constitutive enzyme normally present in tissues. It produces prostaglandins that perform "housekeeping" functions, such as maintaining the protective lining of the stomach and supporting normal kidney function.
- A biological target of NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting cyclooxygenase enzymes. A significant side effect is that they block COX-1 activity, which can reduce the protective prostaglandins in the stomach and lead to issues like gastric irritation.
Usage Examples
- Noun:
- The protective effects on the gastric mucosa are primarily mediated by prostaglandins generated by cyclooxygenase-1.
- Researchers are developing new analgesics that inhibit cyclooxygenase-2 while sparing cyclooxygenase-1 to reduce gastrointestinal side effects.
- An unfortunate side effect of many common pain relievers is that they block cyclooxygenase-1.
Advanced Usage
- "Constitutive cyclooxygenase-1": This phrase emphasizes that the enzyme is normally and consistently present in cells, unlike the inducible COX-2 enzyme.
- Constitutive cyclooxygenase-1 activity is essential for maintaining renal blood flow.
Variants and Related Words
- COX-1: The standard abbreviation for cyclooxygenase-1.
- The drug's selectivity for COX-2 over COX-1 is a key feature.
- Cyclooxygenase (COX): The general term for the enzyme family that includes both COX-1 and COX-2.
- Cyclooxygenase-2 (COX-2): An inducible form of the enzyme primarily associated with inflammation and pain.
Synonyms
- Prostaglandin-endoperoxide synthase 1 (PTGS1): The formal systematic name for the enzyme.
Related Phrases and Concepts
- COX-1 inhibition: The act of blocking the activity of the COX-1 enzyme.
- The gastrointestinal toxicity is linked to COX-1 inhibition.
- COX-1 sparing: A property of drugs designed to avoid inhibiting the COX-1 enzyme.
- The goal of the new medication is COX-1 sparing to protect the stomach lining.
Noun
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an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys
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an unfortunate side effect of NSAIDs is that they block Cox-1
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