cyclooxygenase-1

Thân thiện

A scientist examines a diagram of the cyclooxygenase-1 enzyme in a laboratory.

Definition

1. Noun:
   • An enzyme that regulates prostaglandins important for stomach lining and kidney health: Cyclooxygenase-1 (often abbreviated as COX-1) is a constitutive enzyme normally present in tissues. It produces prostaglandins that perform "housekeeping" functions, such as maintaining the protective lining of the stomach and supporting normal kidney function.
   • A biological target of NSAIDs: Nonsteroidal anti-inflammatory drugs (NSAIDs) work by inhibiting cyclooxygenase enzymes. A significant side effect is that they block COX-1 activity, which can reduce the protective prostaglandins in the stomach and lead to issues like gastric irritation.

Usage Examples

• Noun:
  • The protective effects on the gastric mucosa are primarily mediated by prostaglandins generated by cyclooxygenase-1.
  • Researchers are developing new analgesics that inhibit cyclooxygenase-2 while sparing cyclooxygenase-1 to reduce gastrointestinal side effects.
  • An unfortunate side effect of many common pain relievers is that they block cyclooxygenase-1.

Advanced Usage

• "Constitutive cyclooxygenase-1": This phrase emphasizes that the enzyme is normally and consistently present in cells, unlike the inducible COX-2 enzyme.
  • Constitutive cyclooxygenase-1 activity is essential for maintaining renal blood flow.

Variants and Related Words

• COX-1: The standard abbreviation for cyclooxygenase-1.
  • The drug's selectivity for COX-2 over COX-1 is a key feature.
• Cyclooxygenase (COX): The general term for the enzyme family that includes both COX-1 and COX-2.
• Cyclooxygenase-2 (COX-2): An inducible form of the enzyme primarily associated with inflammation and pain.

Synonyms

• Prostaglandin-endoperoxide synthase 1 (PTGS1): The formal systematic name for the enzyme.

Related Phrases and Concepts

• COX-1 inhibition: The act of blocking the activity of the COX-1 enzyme.
  • The gastrointestinal toxicity is linked to COX-1 inhibition.
• COX-1 sparing: A property of drugs designed to avoid inhibiting the COX-1 enzyme.
  • The goal of the new medication is COX-1 sparing to protect the stomach lining.

Học thuật

Noun

1. an enzyme that regulates prostaglandins that are important for the health of the stomach lining and kidneys
   • an unfortunate side effect of NSAIDs is that they block Cox-1

Từ đồng nghĩa

• cox-1