cyclooxygenase

Thân thiện

A scientist studies the cyclooxygenase enzyme in a laboratory.

Definition

1. Noun:
   • An enzyme: "Cyclooxygenase" refers to either of two closely related enzymes (often abbreviated as COX-1 and COX-2) that are responsible for controlling the production of prostaglandins, which are hormone-like substances involved in inflammation, pain, and fever.
   • A biological target: This enzyme is blocked or inhibited by certain drugs, most notably aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs).

Examples of Usage

• Noun:
  • The drug works by inhibiting the activity of cyclooxygenase.
  • Researchers are studying the differences between the two forms of cyclooxygenase.
  • Aspirin's anti-inflammatory effect is due to its ability to block cyclooxygenase.

Advanced Usage

• "Cyclooxygenase inhibition": The process or action of blocking the cyclooxygenase enzyme.

  • Cyclooxygenase inhibition is the primary mechanism of action for many pain relievers.

• "Cyclooxygenase pathway": The specific biochemical sequence in which the enzyme acts to produce prostaglandins.

  • The cyclooxygenase pathway is a major target for pharmaceutical intervention.

Variants and Related Words

• COX-1 (noun): A common abbreviation for cyclooxygenase-1, a constitutive enzyme involved in maintaining normal bodily functions like protecting the stomach lining.
• COX-2 (noun): A common abbreviation for cyclooxygenase-2, an inducible enzyme primarily associated with inflammation and pain.
• Cyclooxygenase inhibitor (noun): A substance, such as a drug, that blocks the action of cyclooxygenase.

Synonyms

• COX enzyme: A direct synonym using the common abbreviation.
• Prostaglandin-endoperoxide synthase: The formal, systematic name for the enzyme.

Related Phrases

• COX-2 selective inhibitor: A type of drug that specifically blocks the COX-2 form of the enzyme while sparing COX-1.
  • Celecoxib is a COX-2 selective inhibitor.

Related Idioms

(This term is highly technical and scientific; it is not commonly used in idiomatic expressions.)

Học thuật

Noun

1. either of two related enzymes that control the production of prostaglandins and are blocked by aspirin

Từ đồng nghĩa

• cox