cyclooxygenase
Definition
- Noun:
- An enzyme: "Cyclooxygenase" refers to either of two closely related enzymes (often abbreviated as COX-1 and COX-2) that are responsible for controlling the production of prostaglandins, which are hormone-like substances involved in inflammation, pain, and fever.
- A biological target: This enzyme is blocked or inhibited by certain drugs, most notably aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs).
Examples of Usage
- Noun:
- The drug works by inhibiting the activity of cyclooxygenase.
- Researchers are studying the differences between the two forms of cyclooxygenase.
- Aspirin's anti-inflammatory effect is due to its ability to block cyclooxygenase.
Advanced Usage
"Cyclooxygenase inhibition": The process or action of blocking the cyclooxygenase enzyme.
- Cyclooxygenase inhibition is the primary mechanism of action for many pain relievers.
"Cyclooxygenase pathway": The specific biochemical sequence in which the enzyme acts to produce prostaglandins.
- The cyclooxygenase pathway is a major target for pharmaceutical intervention.
Variants and Related Words
- COX-1 (noun): A common abbreviation for cyclooxygenase-1, a constitutive enzyme involved in maintaining normal bodily functions like protecting the stomach lining.
- COX-2 (noun): A common abbreviation for cyclooxygenase-2, an inducible enzyme primarily associated with inflammation and pain.
- Cyclooxygenase inhibitor (noun): A substance, such as a drug, that blocks the action of cyclooxygenase.
Synonyms
- COX enzyme: A direct synonym using the common abbreviation.
- Prostaglandin-endoperoxide synthase: The formal, systematic name for the enzyme.
Related Phrases
- COX-2 selective inhibitor: A type of drug that specifically blocks the COX-2 form of the enzyme while sparing COX-1.
- Celecoxib is a COX-2 selective inhibitor.
Related Idioms
(This term is highly technical and scientific; it is not commonly used in idiomatic expressions.)
Noun
-
either of two related enzymes that control the production of prostaglandins and are blocked by aspirin
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