estrange

/is'treindʤ/
Verb
  1. arouse hostility or indifference in where there had formerly been love, affection, or friendliness
    • She alienated her friends when she became fanatically religious
  2. remove from customary environment or associations
    • years of boarding school estranged the child from her home

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estrange
The long silence began to estrange the two old friends.