haemophilia A
Học thuậtThân thiện
Definition
Noun: * A specific, inherited blood clotting disorder caused by a congenital (present from birth) deficiency or dysfunction of clotting factor VIII (Factor Eight). This condition is an X-linked recessive trait, meaning it occurs almost exclusively in males.
Usage
- The term is used in medical, clinical, and genetic contexts to specify the most common type of hemophilia.
- It is often contrasted with other clotting disorders like haemophilia B (Factor IX deficiency) or von Willebrand disease.
Examples
- "The patient was diagnosed with haemophilia A after presenting with prolonged bleeding following a minor injury."
- "Management of haemophilia A typically involves regular infusions of recombinant factor VIII."
- "Genetic counseling is recommended for families with a history of haemophilia A."
Advanced Usage
- Severity Classification: The condition is often described by its severity, which correlates with the level of functional factor VIII activity in the blood: , , or .
- Inhibitor Development: A serious complication is the "development of inhibitors," where the patient's immune system produces antibodies against the therapeutic factor VIII.
Variants and Related Words
- Hemophilia A: The American English spelling.
- Classic haemophilia: A traditional synonym.
- Factor VIII deficiency: A descriptive medical term for the underlying cause.
- Haemophilia (noun): The general term for the group of bleeding disorders that includes haemophilia A and B.
Synonyms
- Classic haemophilia
- Factor VIII deficiency
Antonyms
- There is no direct medical antonym. One could refer to a or the absence of a bleeding disorder.
Notes
- The term itself is not typically used in idioms or phrasal verbs due to its highly specific medical nature.
- The 'a' in 'haemophilia A' is not an article but part of the proper name, distinguishing it from other types. It is often capitalized.
Noun
- hemophilia caused by a congenital deficiency of factor VIII; occurs almost exclusively in men