Definition

1. Noun:
   • (Genetics) A set of alleles on a single chromosome: A haplotype is a specific combination of alleles (different versions of the same gene) that are physically located close together on the same chromosome. These alleles are often inherited together as a single unit because they are linked.

Usage Examples

• Noun:
  • Researchers identified a specific haplotype associated with increased disease risk.
  • The haplotype was passed down from the mother to all her children.
  • Comparing haplotypes can help trace human migration patterns.

Advanced Usage

• "Haplotype analysis": The study of haplotypes to understand genetic linkage, disease association, or population history.
  • Haplotype analysis revealed a founder effect in the isolated population.
• "Haplotype block": A region of a chromosome where genetic variation is limited, meaning the same haplotype is found in many individuals.
  • The genome was mapped into distinct haplotype blocks.
• "Haplotype phasing": The process of determining which alleles are located together on the same chromosome.
  • Statistical methods are often used for haplotype phasing in large studies.

Variants and Related Words

• Haplogroup (n): A larger genetic population group defined by shared, inherited haplotypes, often used in studies of deep ancestry.
  • His Y-chromosome haplogroup is common in Northern Europe.
• Diplotype (n): The combination of the two haplotypes (one from each parent) for a given set of genes in an individual.

Synonyms

• Allelic combination: A general term for a set of alleles.
• Linked allele set: Emphasizes the genetic linkage of the alleles.

Related Terms (Not Phrasal Verbs)

• Linkage disequilibrium: A non-random association of alleles at different loci on the same chromosome, which is what creates and defines a haplotype.
  • The presence of a haplotype is evidence of linkage disequilibrium.

Noun

1. (genetics) a combination of alleles (for different genes) that are located closely together on the same chromosome and that tend to be inherited together