imipramine
Definition
Noun: A tricyclic antidepressant drug used primarily in the treatment of major depressive disorder and certain anxiety conditions. It works by increasing the levels of certain neurotransmitters, such as norepinephrine and serotonin, in the brain.
Examples of Usage
- The psychiatrist prescribed imipramine for her patient's severe depression.
- Imipramine is an older medication but can be effective when newer antidepressants are not.
- The side effects of imipramine can include dry mouth and drowsiness.
Advanced Usage
- Clinical Context: In medical literature, "imipramine" is often discussed in the context of its mechanism of action, comparing its efficacy and side-effect profile to those of SSRIs (Selective Serotonin Reuptake Inhibitors).
- Historical Context: It may be referred to as a first-generation tricyclic antidepressant, marking a significant development in psychopharmacology.
Variants and Related Words
- Tricyclic Antidepressant (TCA): The class of drugs to which imipramine belongs.
- Desipramine: A metabolite and also a related tricyclic antidepressant drug.
Synonyms
- Antidepressant
- Tricyclic
- Psychoactive drug
Note: The trade names "Imavate" and "Tofranil" are specific brand names for the drug imipramine.
Noun
-
a tricyclic antidepressant (trade names Imavate and Tofranil) used to treat clinical depression
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