spironolactone
Học thuậtThân thiện
Definition
Noun: A synthetic steroid compound used primarily as a potassium-sparing diuretic. It works by blocking the action of the hormone aldosterone in the body, which helps the kidneys remove excess fluid while retaining potassium. It is used to treat conditions such as hypertension (high blood pressure), heart failure, and edema (fluid retention), and to diagnose or treat hyperaldosteronism.
Usage
Spironolactone is used as a medication. It is typically prescribed by a doctor and taken orally in tablet form. - It is used to treat hypertension, heart failure, and edema caused by various conditions. - It is used to manage symptoms of hyperaldosteronism. - It is often used in combination with other diuretics to prevent potassium loss.
Examples
- The doctor prescribed spironolactone to help manage the patient's congestive heart failure and reduce fluid buildup.
- A common side effect of spironolactone is elevated potassium levels, so regular blood tests are required.
- For resistant hypertension, a treatment regimen may include spironolactone alongside other antihypertensive drugs.
Advanced Usage
- In Endocrinology: Spironolactone is a key diagnostic and therapeutic agent for Conn's syndrome (primary hyperaldosteronism).
- In Dermatology: At lower doses, it is sometimes used off-label to treat hormonal acne and hirsutism in women due to its anti-androgen properties.
- Pharmacological Action: It is classified as a competitive aldosterone receptor antagonist in the distal convoluted tubule of the nephron.
Variants and Related Words
- Aldactone: The most common trade name for spironolactone.
- Potassium-sparing diuretic: The class of drugs to which spironolactone belongs.
- Mineralocorticoid receptor antagonist (MRA): A more specific pharmacological classification for spironolactone and similar drugs like eplerenone.
Synonyms
- Aldactone (trademark)
- Potassium-sparing diuretic (class synonym)
- Anti-aldosterone agent
Related Phrases / Compound Terms
- Spironolactone therapy: Refers to the course of treatment using this medication.
- Spironolactone resistance: A clinical situation where the drug does not produce the expected diuretic effect.
Noun
- a synthetic corticosteroid (trade name Aldactone) used to treat hypertension