exacerbation

/eks,æsə:'beiʃn/
Noun
  1. violent and bitter exasperation
    • his foolishness was followed by an exacerbation of their quarrel
  2. action that makes a problem or a disease (or its symptoms) worse
    • the aggravation of her condition resulted from lack of care

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exacerbation
His constant interruptions led to an exacerbation of the argument.