maculate

Adjective
  1. spotted or blotched
  2. morally blemished; stained or impure
Verb
  1. spot, stain, or pollute
    • The townspeople defiled the river by emptying raw sewage into it
  2. make dirty or spotty, as by exposure to air; also used metaphorically
    • The silver was tarnished by the long exposure to the air
    • Her reputation was sullied after the affair with a married man

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maculate
The artist accidentally maculated the clean canvas with a drop of ink.