annoyance

/ə'nɔiəns/
Noun
  1. the act of troubling or annoying someone
  2. something or someone that causes trouble; a source of unhappiness
    • washing dishes was a nuisance before we got a dish washer
    • a bit of a bother
    • he's not a friend, he's an infliction
  3. an unpleasant person who is annoying or exasperating
  4. anger produced by some annoying irritation
  5. the psychological state of being irritated or annoyed

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annoyance
The constant buzzing of a fly is a major annoyance.